Publikationen

2022

Originalartikel

Kühnen P, Clément K. Long-Term MC4R Agonist Treatment in POMC-Deficient Patients. N Engl J Med. 2022 Sep 1;387(9):852-854. doi: 10.1056/NEJMc2207442. PMID: 36053514.

Wabitsch M, Fehnel S, Mallya UG, Sluga-O'Callaghan M, Richardson D, Price M, Kühnen P. Understanding the Patient Experience of Hunger and Improved Quality of Life with Setmelanotide Treatment in POMC and LEPR Deficiencies. Adv Ther. 2022 Apr;39(4):1772-1783. doi: 10.1007/s12325-022-02059-8. Epub 2022 Feb 22. PMID: 35192151; PMCID: PMC8862005.

Kühnen P, Wabitsch M, von Schnurbein J, Chirila C, Mallya UG, Callahan P, Gnanasakthy A, Poitou C, Krabusch PM, Stewart M, Clément K. Quality of life outcomes in two phase 3 trials of setmelanotide in patients with obesity due to LEPR or POMC deficiency. Orphanet J Rare Dis. 2022 Feb 5;17(1):38. doi: 10.1186/s13023-022-02186-z. PMID: 35123544; PMCID: PMC8817523.

Overberg J, Kalveram L, Keller T, Krude H, Kühnen P, Wiegand S. Interactions between nocturnal melatonin secretion, metabolism, and sleeping behavior in adolescents with obesity. Int J Obes (Lond). 2022 May;46(5):1051-1058. doi: 10.1038/s41366-022-01077-4. Epub 2022 Feb 9. PMID: 35140394; PMCID: PMC9050511.

Kempf E, Landgraf K, Stein R, Hanschkow M, Hilbert A, Abou Jamra R, Boczki P, Herberth G, Kühnapfel A, Tseng YH, Stäubert C, Schöneberg T, Kühnen P, Rayner NW, Zeggini E, Kiess W, Blüher M, Körner A. Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity. Nat Metab. 2022 Dec;4(12):1697-1712. doi: 10.1038/s42255-022-00703-9. Epub 2022 Dec 19. PMID: 36536132; PMCID: PMC9771800.

Reininghaus N, Paisdzior S, Höpfner F, Jyrch S, Cetindag C, Scheerer P, Kühnen P, Biebermann H. A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation. Biomolecules. 2022 Aug 15;12(8):1119. doi: 10.3390/biom12081119. PMID: 36009013; PMCID: PMC9405727.

Höpfner F, Paisdzior S, Reininghaus N, Sohail I, Scheerer P, Annibale P, Biebermann H, Kühnen P. Evaluation of Pharmacological Rescue of Melanocortin-4 Receptor Nonsense Mutations by Aminoglycoside. Life (Basel). 2022 Nov 5;12(11):1793. doi: 10.3390/life12111793. PMID: 36362948; PMCID: PMC9697516.

Boss M, Rottenburger C, Brenner W, Blankenstein O, Prasad V, Prasad S, Coppi P, Kühnen P, Buitinga M, Nuutila P, Otonkoski T, Hussain K, Brom M, Eek A, Bomanji J, Shah P, Gotthardt M. ⁶⁸Ga-NODAGA-Exendin-4 PET/CT Improves the Detection of Focal Congenital Hyperinsulinism. J Nucl Med. 2022 Feb;63(2):310-315. doi: 10.2967/jnumed.121.262327. Epub 2021 Jul 2. PMID: 34215672; PMCID: PMC8805776.

Graffunder AS, Paisdzior S, Opitz R, Renko K, Kühnen P, Biebermann H. Design and Characterization of a Fluorescent Reporter Enabling Live-cell Monitoring of MCT8 Expression. Exp Clin Endocrinol Diabetes. 2022 Feb;130(2):134-140. doi: 10.1055/a-1522-8535. Epub 2021 Aug 5. PMID: 34352913.

2021

Originalartikel

Poitou C, Puder L, Dubern B, Krabusch P, Genser L, Wiegand S, Verkindt H, Köhn A, von Schwartzenberg RJ, Flück C, Pattou F, Laville M, Kühnen P, Clément K. Long-term outcomes of bariatric surgery in patients with bi-allelic mutations in the POMC, LEPR, and MC4R genes. Surg Obes Relat Dis. 2021 Aug;17(8):1449-1456. doi: 10.1016/j.soard.2021.04.020. Epub 2021 May 8. PMID: 34083135.

Kanti V, Puder L, Jahnke I, Krabusch PM, Kottner J, Vogt A, Richter C, Andruck A, Lechner L, Poitou C, Krude H, Gottesdiener K, Clément K, Farooqi IS, Wiegand S, Kühnen P, Blume-Peytavi U. A Melanocortin-4 Receptor Agonist Induces Skin and Hair Pigmentation in Patients with Monogenic Mutations in the Leptin-Melanocortin Pathway. Skin Pharmacol Physiol. 2021;34(6):307-316. doi: 10.1159/000516282. Epub 2021 May 31. PMID: 34058738.

Puder L, Roth S, Krabusch P, Wiegand S, Opitz R, Bald M, Flück C, Schulz E, Voss E, Markó L, Linz P, Berger F, Müller DN, Kuehne T, Litt MJ, Cone RD, Kühnen P, Kelm M. Cardiac Phenotype and Tissue Sodium Content in Adolescents With Defects in the Melanocortin System. J Clin Endocrinol Metab. 2021 Aug 18;106(9):2606-2616. doi: 10.1210/clinem/dgab368. PMID: 34036349; PMCID: PMC8372645.

Fischer I, Küchler J, Schaar C, Fisch T, Cernoch J, Fischer K, Fernández Vallone V, Kühnen P, Stachelscheid H. Generation of human induced pluripotent stem cell lines from 2 patients with MIRAGE syndrome. Stem Cell Res. 2021 Jul;54:102417. doi: 10.1016/j.scr.2021.102417. Epub 2021 Jun 10. PMID: 34119956.

Kalveram L, Gohlisch J, Brauchmann J, Overberg J, Kühnen P, Wiegand S. Gustatory Function Can Improve after Multimodal Lifestyle Intervention: A Longitudinal Observational Study in Pediatric Patients with Obesity. Child Obes. 2021 Mar;17(2):136-143. doi: 10.1089/chi.2020.0318. Epub 2021 Feb 1. PMID: 33524304.

Porst T, Johannes J, Gluschke H, Köhler R, Mehl S, Kühnen P, Renko K, Minich WB, Wiegand S, Schomburg L. Natural Autoimmunity to the Thyroid Hormone Monocarboxylate Transporters MCT8 and MCT10. Biomedicines. 2021 Apr 30;9(5):496. doi: 10.3390/biomedicines9050496. PMID: 33946552; PMCID: PMC8147215.

2020

Originalartikel

Clément K, van den Akker E, Argente J, Bahm A, Chung WK, Connors H, De Waele K, Farooqi IS, Gonneau-Lejeune J, Gordon G, Kohlsdorf K, Poitou C, Puder L, Swain J, Stewart M, Yuan G, Wabitsch M, Kühnen P; Setmelanotide POMC and LEPR Phase 3 Trial Investigators. Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials. Lancet Diabetes Endocrinol. 2020 Dec;8(12):960-970. doi: 10.1016/S2213-8587(20)30364-8. Epub 2020 Oct 30. PMID: 33137293.

Wilpert NM, Krueger M, Opitz R, Sebinger D, Paisdzior S, Mages B, Schulz A, Spranger J, Wirth EK, Stachelscheid H, Mergenthaler P, Vajkoczy P, Krude H, Kühnen P, Bechmann I, Biebermann H. Spatiotemporal Changes of Cerebral Monocarboxylate Transporter 8 Expression. Thyroid. 2020 Sep;30(9):1366-1383. doi: 10.1089/thy.2019.0544. Epub 2020 Apr 17. PMID: 32143555.

2019

Originalartikel

Gong M, Yu Y, Liang L, Vuralli D, Froehler S, Kuehnen P, Du Bois P, Zhang J, Cao A, Liu Y, Hussain K, Fielitz J, Jia S, Chen W, Raile K. HDAC4 mutations cause diabetes and induce β-cell FoxO1 nuclear exclusion. Mol Genet Genomic Med. 2019 May;7(5):e602. doi: 10.1002/mgg3.602. Epub 2019 Apr 9. PMID: 30968599; PMCID: PMC6503015.

Heyder N, Kleinau G, Szczepek M, Kwiatkowski D, Speck D, Soletto L, Cerdá-Reverter JM, Krude H, Kühnen P, Biebermann H, Scheerer P. Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective. Front Endocrinol (Lausanne). 2019 Jul 31;10:515. doi: 10.3389/fendo.2019.00515. PMID: 31417496; PMCID: PMC6685040.

Jacobi SF, Khajavi N, Kleinau G, Teumer A, Scheerer P, Homuth G, Völzke H, Wiegand S, Kühnen P, Krude H, Gong M, Raile K, Biebermann H. Evaluation of a rare glucose-dependent insulinotropic polypeptide receptor variant in a patient with diabetes. Diabetes Obes Metab. 2019 May;21(5):1168-1176. doi: 10.1111/dom.13634. Epub 2019 Feb 19. PMID: 30784161.

Jessen E, Vetter C, Roenneberg T, Liesenkötter KP, Werner H, Jenni OG, Lankes E, Blankenstein O, Neumann U, Köhler B, Wiegand S, Krude H, Kühnen P. Sleep Timing in Patients with Precocious and Delayed Pubertal Development. Clocks Sleep. 2019 Feb 16;1(1):140-150. doi: 10.3390/clockssleep1010013. PMID: 33089160; PMCID: PMC7509672.

2018

Originalartikel

Mai K, Li L, Wiegand S, Brachs M, Leupelt V, Ernert A, Kühnen P, Hübner N, Robinson P, Chen W, Krude H, Spranger J. An Integrated Understanding of the Molecular Mechanisms of How Adipose Tissue Metabolism Affects Long-term Body Weight Maintenance. Diabetes. 2019 Jan;68(1):57-65. doi: 10.2337/db18-0440. Epub 2018 Nov 2. PMID: 30389745.

Clément K, Biebermann H, Farooqi IS, Van der Ploeg L, Wolters B, Poitou C, Puder L, Fiedorek F, Gottesdiener K, Kleinau G, Heyder N, Scheerer P, Blume-Peytavi U, Jahnke I, Sharma S, Mokrosinski J, Wiegand S, Müller A, Weiß K, Mai K, Spranger J, Grüters A, Blankenstein O, Krude H, Kühnen P. MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency. Nat Med. 2018 May;24(5):551-555. doi: 10.1038/s41591-018-0015-9. Epub 2018 May 7. PMID: 29736023.

Aleksander PE, Brückner-Spieler M, Stoehr AM, Lankes E, Kühnen P, Schnabel D, Ernert A, Stäblein W, Craig ME, Blankenstein O, Grüters A, Krude H. Mean High-Dose l-Thyroxine Treatment Is Efficient and Safe to Achieve a Normal IQ in Young Adult Patients With Congenital Hypothyroidism. J Clin Endocrinol Metab. 2018 Apr 1;103(4):1459-1469. doi: 10.1210/jc.2017-01937. PMID: 29325045.

Neumann U, Bührer C, Blankenstein O, Kühnen P, Raile K. Primary sulphonylurea therapy in a newborn with transient neonatal diabetes attributable to a paternal uniparental disomy 6q24 (UPD6). Diabetes Obes Metab. 2018 Feb;20(2):474-475. doi: 10.1111/dom.13085. Epub 2017 Oct 5. PMID: 28817249.

Fischer J, Kleinau G, Rutz C, Zwanziger D, Khajavi N, Müller A, Rehders M, Brix K, Worth CL, Führer D, Krude H, Wiesner B, Schülein R, Biebermann H. Evidence of G-protein-coupled receptor and substrate transporter heteromerization at a single molecule level. Cell Mol Life Sci. 2018 Jun;75(12):2227-2239. doi: 10.1007/s00018-017-2728-1. Epub 2017 Dec 30. PMID: 29290039.

vor 2018

Originalartikel

Hildebrand L, Gaber T, Kühnen P, Morhart R, Unterbörsch H, Schomburg L, Seemann P. Trace element and cytokine concentrations in patients with Fibrodysplasia Ossificans Progressiva (FOP): A case control study. J Trace Elem Med Biol. 2017 Jan;39:186-192. doi: 10.1016/j.jtemb.2016.10.001. Epub 2016 Oct 4. PMID: 27908413.

Kühnen P, Handke D, Waterland RA, Hennig BJ, Silver M, Fulford AJ, Dominguez-Salas P, Moore SE, Prentice AM, Spranger J, Hinney A, Hebebrand J, Heppner FL, Walzer L, Grötzinger C, Gromoll J, Wiegand S, Grüters A, Krude H. Interindividual Variation in DNA Methylation at a Putative POMC Metastable Epiallele Is Associated with Obesity. Cell Metab. 2016 Sep 13;24(3):502-509. doi: 10.1016/j.cmet.2016.08.001. Epub 2016 Aug 25. PMID: 27568547.

Kühnen P, Clément K, Wiegand S, Blankenstein O, Gottesdiener K, Martini LL, Mai K, Blume-Peytavi U, Grüters A, Krude H. Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist. N Engl J Med. 2016 Jul 21;375(3):240-6. doi: 10.1056/NEJMoa1512693. PMID: 27468060.

Gögebakan Ö, Andres J, Biedasek K, Mai K, Kühnen P, Krude H, Isken F, Rudovich N, Osterhoff MA, Kintscher U, Nauck M, Pfeiffer AF, Spranger J. Glucose-dependent insulinotropic polypeptide reduces fat-specific expression and activity of 11β-hydroxysteroid dehydrogenase type 1 and inhibits release of free fatty acids. Diabetes. 2012 Feb;61(2):292-300. doi: 10.2337/db10-0902. Epub 2011 Dec 16. PMID: 22179810; PMCID: PMC3266397.

Kuehnen P, Mischke M, Wiegand S, Sers C, Horsthemke B, Lau S, Keil T, Lee YA, Grueters A, Krude H. An Alu element-associated hypermethylation variant of the POMC gene is associated with childhood obesity. PLoS Genet. 2012;8(3):e1002543. doi: 10.1371/journal.pgen.1002543. Epub 2012 Mar 15. PMID: 22438814; PMCID: PMC3305357.

Kuehnen P, Laubner K, Raile K, Schöfl C, Jakob F, Pilz I, Päth G, Seufert J. Protein phosphatase 1 (PP-1)-dependent inhibition of insulin secretion by leptin in INS-1 pancreatic β-cells and human pancreatic islets. Endocrinology. 2011 May;152(5):1800-8. doi: 10.1210/en.2010-1094. Epub 2011 Mar 22. PMID: 21427225.

Kuehnen P, Grueters A, Krude H. Two puzzling cases of thyroid dysgenesis. Horm Res. 2009 Jan;71 Suppl 1:93-7. doi: 10.1159/000178047. Epub 2009 Jan 21. PMID: 19153515.

Braune K, Volkmer I, Staege MS. Characterization of Alstrom Syndrome 1 (ALMS1) Transcript Variants in Hodgkin Lymphoma Cells. PLoS One. 2017 Jan 30; 12(1): e0170694. doi: 10.1371/journal.pone.0170694. eCollection 2017. PMID: 28135309

Mühlhaus J, Dinter J, Jyrch S, Teumer A, Jacobi SF, Homuth G, Kühnen P, Wiegand S, Grüters A, Völzke H, Raile K, Kleinau G, Krude H, Biebermann H. Investigation of Naturally Occurring Single-Nucleotide Variants in Human TAAR1. Front Pharmacol. 2017 Nov 24; 8: 807. doi: 10.3389/fphar.2017.00807. eCollection 2017. PMID: 29225575

Hörtenhuber T, Kiess W, Fröhlich-Reiterer E, Raile K, Stachow R, Bollow E, Rami-Merhar B, Holl RW; DPV-Wiss Study Group. Asthma in children and adolescents with type 1 diabetes in Germany and Austria: Frequency and metabolic control. Pediatr Diabetes. 2017 Dec 8. doi: 10.1111/pedi.12618. PMID: 29218837

Pacaud D, Hermann JM, Karges B, Rosenbauer J, Danne T, Dürr R, Herbst A, Lindauer S, Müther S, Pötzsch S, Raile K, Witsch M, Holl RW; DPV Initiative. Risk of recurrent severe hypoglycemia remains associated with a past history of severe hypoglycemia up to 4 years: Results from a large prospective contemporary pediatric cohort of the DPV initiative. Pediatr Diabetes. 2017 Dec 8. doi: 10.1111/pedi.12610. [Epub ahead of print] PMID: 29218766

Grüters-Kieslich A, Reyes M, Sharma A, Demirci C, DeClue TJ, Lankes E, Tiosano D, Schnabel D, Jüppner H. Early-Onset Obesity: Unrecognized First Evidence for GNAS Mutations and Methylation Changes. J Clin Endocrinol Metab. 2017 Aug 1; 102(8): 2670-2677. doi: 10.1210/jc.2017-00395. PMID: 28453643

Puder LC, Wilitzki S, Bührer C, Fischer HS, Schmalisch G. Computerized wheeze detection in young infants: comparison of signals from tracheal and chest wall sensors. Physiol Meas. 2016 Dec;37(12):2170-2180. Epub 2016 Nov 21. PMID: 27869106

Fischer HS, Puder LC, Wilitzki S, Usemann J, Bührer C, Godfrey S, Schmalisch G. Relationship between computerized wheeze detection and lung function parameters in young infants. Pediatr Pulmonol. 2016 Apr; 51(4): 402-10. doi: 10.1002/ppul.23310. Epub 2015 Sep 11. PMID: 26360639

Glaudo M, Letz S, Quinkler M, Bogner U, Elbelt U, Strasburger CJ, Schnabel D, Lankes E, Scheel S, Feldkamp J, Haag C, Schulze E, Frank-Raue K, Raue F, Mayr B, Schöfl C. Heterozygous inactivating CaSR mutations causing neonatal hyperparathyroidism: function, inheritance and phenotype. Eur J Endocrinol. 2016 Nov; 175(5): 421-31. doi: 10.1530/EJE-16-0223. PMID: 27666534

Raile K, Schober E, Konrad K, Thon A, Grulich-Henn J, Meissner T, Wölfle J, Scheuing N, Holl RW; DPV Initiative the German BMBF Competence Network Diabetes Mellitus. Treatment of young patients with HNF1A mutations (HNF1A-MODY). Diabet Med. 2015 Apr; 32(4): 526-30. doi: 10.1111/dme.12662. Epub 2014 Dec 30. PMID: 25483937

Ottenhausen M, Bittigau P, Koch A, Lankes E, Schulz M, Thomale UW. Hamartoma of the optic nerve in a young child—case report and review of the literature. Childs Nerv Syst. 2015 Aug;31(8):1401-6. doi: 10.1007/s00381-015-2727-1. Epub 2015 Apr 30. Review. PMID: 25925579

Puder LC, Fischer HS, Wilitzki S, Usemann J, Godfrey S, Schmalisch G. Validation of computerized wheeze detection in young infants during the first months of life. BMC Pediatr. 2014 Oct 9; 14: 257. doi: 10.1186/1471-2431-14-257. PMID: 25296955

Dost A, Molz E, Krebs A, Bechtold S, Kapellen T, Rohrer T, Raile K, Fritsch M, Schwab KO, Holl R. Pulse pressure in children and adolescents with type 1 diabetes mellitus in Germany and Austria. Pediatr Diabetes. 2014 May; 15(3): 236-43. PMID: 25705749

Hofer SE, Raile K, Fröhlich-Reiterer E, Kapellen T, Dost A, Rosenbauer J, Grulich-Henn J, Holl RW; Austrian/German Diabetes Patienten Verlaufsdokumentation DPV Initiative; German Competence Network for Diabetes Mellitus. Tracking of metabolic control from childhood to young adulthood in type 1 diabetes. J Pediatr. 2014 Nov; 165(5): 956-61.e1-2. doi: 10.1016/j.jpeds.2014.07.001. Epub 2014 Aug 20. PMID: 25151197

Bechtold S, Blaschek A, Raile K, Dost A, Freiberg C, Askenas M, Fröhlich-Reiterer E, Molz E, Holl RW. Higher relative risk for multiple sclerosis in a pediatric and adolescent diabetic population: analysis from DPV database. Diabetes Care. 2014; 37(1): 96-101. doi: 10.2337/dc13-1414. Epub 2013 Aug 29. PMID: 23990514

Holterhus PM, Bokelmann J, Riepe F, Heidtmann B, Wagner V, Rami-Merhar B, Kapellen T, Raile K, Quester W, Holl RW; German/Austrian DPV-Initiative and the German Pediatric CSII Working Group. Predicting the optimal basal insulin infusion pattern in children and adolescents on insulin pumps. Diabetes Care. 2013 Jun; 36(6): 1507-11. doi: 10.2337/dc12-1705. Epub 2013 Feb 12. PMID: 23404300

Muhn F, Klopocki E, Graul-Neumann L, Uhrig S, Colley A, Castori M, Lankes E, Henn W, Gruber-Sedlmayr U, Seifert W, Horn D. Novel mutations of the PRKAR1A gene in patients with acrodysostosis. Clin Genet. 2013 Dec; 84(6): 531-8. doi: 10.1111/cge.12106. Epub 2013 Feb 21. PMID: 23425300

Gong M, Simaite D, Kühnen P, Heldmann M, Spagnoli F, Blankenstein O, Hübner N, Hussain K, Raile K. Two novel GATA6 mutations cause childhood-onset diabetes mellitus, pancreas malformation and congenital heart disease. Horm Res Paediatr. 2013; 79(4): 250-6. doi: 10.1159/000348844. Epub 2013 Apr 26. PMID: 23635550

Kühnen P, Marquard J, Ernert A, Meissner T, Raile K, Wannenmacher G, Blankenstein O. Long-term lanreotide treatment in six patients with congenital hyperinsulinism. Horm Res Paediatr. 2012; 78(2): 106-12. Epub 2012 Aug 14. PMID: 22907123

Ludvigsson J, Krisky D, Casas R, Battelino T, Castaño L, Greening J, Kordonouri O, Otonkoski T, Pozzilli P, Robert JJ, Veeze HJ, Palmer J, Samuelsson U, Elding Larsson H, Åman J, Kärdell G, Neiderud Helsingborg J, Lundström G, Albinsson E, Carlsson A, Nordvall M, Fors H, Arvidsson CG, Edvardson S, Hanås R, Larsson K, Rathsman B, Forsgren H, Desaix H, Forsander G, Nilsson NÖ, Åkesson CG, Keskinen P, Veijola R, Talvitie T, Raile K, Kapellen T, Burger W, Neu A, Engelsberger I, Heidtmann B, Bechtold S, Leslie D, Chiarelli F, Cicognani A, Chiumello G, Cerutti F, Zuccotti GV, Gomez Gila A, Rica I, Barrio R, Clemente M, López Garcia MJ, Rodriguez M, Gonzalez I, Lopez JP, Oyarzabal M, Reeser HM, Nuboer R, Stouthart P, Bratina N, Bratanic N, de Kerdanet M, Weill J, Ser N, Barat P, Bertrand AM, Carel JC, Reynaud R, Coutant R, Baron S. GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus. N Engl J Med. 2012 Feb 2; 366(5): 433-42. doi: 10.1056/NEJMoa1107096. PMID: 22296077

Galler A, Haberland H, Näke A, Hofer S, Holder M, Raile K, Holl RW; German Federal Ministry for Education and Research BMBF Competence Network of Diabetes Mellitus. Natural course of untreated microalbuminuria in children and adolescents with type 1 diabetes and the importance of diabetes duration and immigrant status: longitudinal analysis from the prospective nationwide German and Austrian diabetes survey DPV. Eur J Endocrinol. 2012 Mar; 166(3): 493-501. doi: 10.1530/EJE-11-0695. Epub 2011 Dec 23. PMID: 22199141

Ludwig-Seibold CU, Holder M, Rami B, Raile K, Heidtmann B, Holl RW; DPV Science Initiative; German Working Group for insulin pump treatment in pediatric patients; German BMBF Competence Network Diabetes. Continuous glucose monitoring in children, adolescents, and adults with type 1 diabetes mellitus: analysis from the prospective DPV diabetes documentation and quality management system from Germany and Austria. Pediatr Diabetes. 2012 Feb; 13(1): 12-4. doi: 10.1111/j.1399-5448.2011.00835.x. Epub 2011 Nov 29. PMID: 22128781